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In 8 patients with cirrhosis second to alcoholic abuse, the mean total clearance of methocarbamol was lessened about 70 % as compared to that acquired in 8 age- and weight-matched normal topics.

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The clearance of methocarbamol in 8 renally-impaired individuals on upkeep hemodialysis was lowered regarding 40 % as compared to 17 normal subjects, although the mean ( ± SD) elimination half-life in these two teams was similar (1.2 ( ± 0.6) versus 1.1 ( ± 0.3) hours, respectively).